Product Details

IGF-1 LR3 (Media Grade) is a synthetic peptide analog of insulin-like growth factor-1 (IGF-1), modified to alter its structural and receptor interaction properties. This modification supports extended stability and enables detailed investigation in controlled research environments.

Within laboratory settings, IGF-1 LR3 is utilized to examine receptor-ligand interactions and intracellular signaling pathways associated with growth factor systems. Its structure allows for consistent evaluation of peptide binding dynamics and signal transduction mechanisms at the molecular level.

This compound is supplied strictly for laboratory research purposes and is not intended for consumption, medical, or diagnostic use.

Mechanism of Action

At the molecular level, IGF-1 LR3 is studied for its interaction with insulin-like growth factor-1 receptors (IGF-1R) and related receptor systems. Upon binding, the receptor-ligand complex initiates intracellular signaling cascades involving pathways such as phosphoinositide 3-kinase (PI3K) and protein kinase B (Akt), as well as mitogen-activated protein kinase (MAPK) signaling.

These signaling pathways are analyzed in vitro to evaluate their role in cellular communication, transcriptional regulation, and protein synthesis processes. Researchers examine how ligand binding influences receptor activation, downstream signaling propagation, and gene expression patterns.

Additionally, IGF-1 LR3 is investigated for its interaction with insulin-like growth factor binding proteins (IGFBPs), which regulate peptide availability and receptor engagement. These studies contribute to a broader understanding of growth factor signaling and molecular regulation under controlled experimental conditions.

Chemical Properties of IGF-1 LR3 (Media Grade)

Attribute	Details
Compound Name	IGF-1 LR3
Classification	Synthetic peptide (IGF-1 analog)
Molecular Formula	C400H625N111O115S9
Molecular Weight	9117.60 g/mol
CAS Number	946870-92-4
IUPAC Name	Insulin-like growth factor-1 long arginine 3
Synonyms	IGF-I; IGF1A; IGFI
Primary Target	IGF-1 receptor (IGF-1R)
Research Context	Growth factor signaling and receptor interaction studies
Format	Research peptide (non-consumable)
Stability	Maintained under controlled laboratory storage conditions

Research Applications

Receptor Binding and Signal Transduction Studies

IGF-1 LR3 is utilized in experimental systems to evaluate ligand interaction with IGF-1 receptors. Researchers analyze receptor activation, binding affinity, and downstream signaling cascades at the molecular level.

Intracellular Pathway Analysis

This compound is applied in studies investigating signaling pathways such as PI3K/Akt and MAPK. These analyses focus on transcriptional regulation and protein synthesis mechanisms associated with receptor activation.

Peptide-Protein Interaction Research

IGF-1 LR3 supports investigations into interactions with binding proteins such as IGFBPs. These studies examine how binding proteins influence peptide stability, availability, and receptor engagement.

Why Choose BehemothLabz to Buy IGF-1 LR3 for Research

BehemothLabz provides research-grade IGF-1 LR3 manufactured under controlled laboratory conditions with strict quality assurance protocols. Each batch undergoes analytical verification to ensure consistency in molecular composition and purity.

Comprehensive documentation, including laboratory testing reports and sourcing transparency, supports reproducibility in experimental settings. BehemothLabz maintains a compliance-focused approach, supplying compounds intended strictly for laboratory-based investigation and analytical research

Disclaimer

IGF-1 LR3 is intended strictly for laboratory research and analytical purposes only. It is not intended for use in diagnostic procedures, therapeutic applications, or in vivo studies of any kind.

Any references to biochemical pathways, receptor interactions, or enzymatic processes are provided solely for informational and research-context purposes. This compound must be handled exclusively by qualified professionals in controlled laboratory environments in accordance with applicable regulations and safety guidelines.

Improper handling or use outside of controlled research settings is strictly prohibited.

References

White, A., Stremming, J., Wesolowski, S. R., Al-Juboori, S. I., Dobrinskikh, E., Limesand, S. W., Brown, L. D., & Rozance, P. J. (2025). IGF-1 LR3 does not promote growth in late-gestation growth-restricted fetal sheep. American journal of physiology. Endocrinology and metabolism, 328(1), E116–E125. https://doi.org/10.1152/ajpendo.00259.2024
Lu, Z., Liu, N., Huang, H., Wang, Y., Tu, T., Qin, X., Wang, X., Zhang, J., Su, X., Tian, J., Bai, Y., Luo, H., Yao, B., & Zhang, H. (2023). Recombinant expression of IGF-1 and LR3 IGF-1 fused with xylanase in Pichia pastoris. Applied microbiology and biotechnology, 107(14), 4543–4551. https://doi.org/10.1007/s00253-023-12606-0