Product Details – Letrozole

Letrozole is a nonsteroidal aromatase inhibitor belonging to the triazole class of compounds. It is widely utilized in investigational research for the study of estrogen biosynthesis and endocrine pathway modulation.

In experimental models, letrozole serves as a potent and selective inhibitor of the aromatase enzyme (CYP19A1), making it a valuable tool in in vitro studies focused on steroidogenesis and hormonal regulation at the molecular level.

Mechanism of Action

Letrozole functions through competitive inhibition of the aromatase enzyme, a cytochrome P450-dependent monooxygenase responsible for the conversion of androgens into estrogens.

In preclinical models, letrozole binds to the heme group of the aromatase enzyme via its triazole ring, thereby preventing substrate access and catalytic activity. This inhibition disrupts estrogen biosynthesis pathways, allowing researchers to examine downstream effects on gene expression, receptor signaling, and endocrine feedback mechanisms in research models.

Properties

Molecular Formula: C17H11N5
Molecular Weight: 285.31 g/mol
CAS Number: 112809-51-5
PubChem CID: 3902
Synonyms: Femara, Letoval, Letz, Trozet, Oncolet, Letcoz, Letroz, Letrosyn

Research Applications

Letrozole is extensively applied in investigational research involving estrogen biosynthesis and endocrine system regulation.

Common uses in in vitro and experimental models include:

Investigation of aromatase (CYP19A1) enzyme inhibition kinetics
Study of steroidogenesis pathways and estrogen synthesis regulation
Analysis of estrogen-dependent gene expression and signaling networks
Use as a reference compound in comparative studies of aromatase inhibitors
Evaluation of endocrine feedback mechanisms in preclinical models

Its selectivity and potency make letrozole a critical compound for mechanistic studies of estrogen production and regulation in molecular and cellular research systems.

Why Choose BehemothLabz to Buy Letrozole

Choose BehemothLabz for research-focused quality and consistency. Our Letrozole are manufactured to meet rigorous standards suitable for laboratory and experimental use.

Each batch undergoes third-party testing to verify purity, composition, and consistency. This ensures that researchers receive a product aligned with strict analytical requirements.

We offer secure ordering systems and reliable shipping options for both domestic and international customers. Our processes are designed to maintain confidentiality and protect customer data at every stage.

With BehemothLabz, you are selecting a product developed to support precision and reliability in research environments.

Disclaimer: This information is for educational purposes. We do not allow the human consumption of our products. All our products are sold for laboratory and research experiments.

References:

Finn, R. S., Martin, M., Rugo, H. S., Jones, S., Im, S., Gelmon, K., Harbeck, N., Lipatov, O. N., Walshe, J. M., Moulder, S., Gauthier, E., Lu, D. R., Randolph, S., Diéras, V., & Slamon, D. J. (2016). Palbociclib and letrozole in advanced breast cancer. New England Journal of Medicine, 375(20), 1925–1936. https://doi.org/10.1056/nejmoa1607303
Legro, R. S., Brzyski, R. G., Diamond, M. P., Coutifaris, C., Schlaff, W. D., Casson, P., Christman, G. M., Huang, H., Yan, Q., Alvero, R., Haisenleder, D. J., Barnhart, K. T., Bates, G. W., Usadi, R., Lucidi, S., Baker, V., Trussell, J., Krawetz, S. A., Snyder, P., . . . Zhang, H. (2014). Letrozole versus Clomiphene for Infertility in the Polycystic Ovary Syndrome. New England Journal of Medicine, 371(2), 119–129. https://doi.org/10.1056/nejmoa1313517

Letrozole

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