FLModafinil (CRL-40,940) Capsules

What Is FLModafinil (CRL-40,940)?

FLModafinil — also written as fl modafinil, and known by the identifiers CRL-40,940, Bisfluoromodafinil, and Lauflumide — is a synthetic eugeroic compound in the wakefulness-promoting class of CNS-active research chemicals. Structurally, it is the bis(para-fluoro) derivative of Modafinil, defined by the substitution of two fluorine atoms at the para positions of Modafinil’s phenyl rings.

For researchers looking to buy FLModafinil for laboratory use, BehemothLabz supplies it as third-party tested FLModafinil capsules formulated exclusively for preclinical and experimental research settings.

This structural modification is precisely what makes CRL-40,940 a high-value probe in studies of dopamine transporter (DAT) selectivity, wake-promoting neural circuits, and structure-activity relationships (SAR) across the eugeroic compound class.

Physicochemical Profile

FLModafinil vs Modafinil vs Adrafinil — Preclinical Research Comparison

Mechanism of Action — How Does FLModafinil Work?

FLModafinil’s primary mechanism of action in preclinical models is interaction with the dopamine transporter (DAT). As a dopamine reuptake inhibitor, CRL-40,940 limits the reabsorption of dopamine back into the presynaptic neuron — extending dopamine’s presence within the synaptic cleft in experimental laboratory settings.

DAT Selectivity over SERT and NET

CRL-40,940 binds DAT with higher affinity than Modafinil in preclinical models. This selectivity allows researchers to study DAT-mediated dopaminergic dynamics with reduced off-target interference from serotonergic or noradrenergic pathways.

No CYP450 Enzyme Induction

Unlike some CNS-active research chemicals, FLModafinil does not appear to induce CYP450 enzyme activity in laboratory models. For studies designed to isolate dopaminergic transporter effects, this is a significant methodological advantage.

Nucleus Accumbens Shell Specificity

Published voltammetry and microdialysis data (Keighron et al., ACS Chemical Neuroscience, 2019) confirm that CRL-40,940 modulates dopamine dynamics specifically in the nucleus accumbens shell — a region central to reward circuitry, motivation, and arousal research.

What Does “Eugeroic” Mean in Research Pharmacology?

A eugeroic is a pharmacological class of compounds that promotes wakefulness and sustained arousal without the classic stimulant mechanism of amphetamine-class molecules. The term derives from the Greek for “good arousal.” As a eugeroic research chemical, FLModafinil is studied specifically for its wake-promoting mechanisms and how they differ from those of classical psychostimulants.

Buy FLModafinil (CRL-40,940) from BehemothLabz

FLModafinil Capsules for Sale — Research Use Only

Researchers looking to buy FLModafinil can source BehemothLabz CRL-40,940 capsules with confidence in purity, documentation, and research-grade formulation. BehemothLabz is a trusted supplier of FLModafinil for sale for laboratory and preclinical research settings.

What Sets BehemothLabz Apart

Independent third-party testing — every batch. Every lot of FLModafinil capsules is sent to external laboratories for verification. BehemothLabz does not rely on in-house testing alone.

Public Certificate of Analysis (COA) per lot. Each product listing carries a publicly accessible COA showing purity percentage and concentration data. Before conducting any experiment, researchers can verify exactly what they’re receiving. Batch-level documentation supports reproducible research protocols.

Consistent, research-grade formulation. Lot-to-lot consistency is verified through COA documentation — critical for longitudinal studies and comparative compound profiling.

What Researchers Receive

• FLModafinil (CRL-40,940) capsules at independently verified research purity
• Public COA from third-party laboratory testing
• Research-use-only labeling compliant with applicable standards
• Customer support at **support@behemothlabz.com** for storage and handling inquiries

Research Applications of FLModafinil (CRL-40,940)

Where Does FLModafinil Fit as a Research Chemical?

As a FLModafinil research chemical, CRL-40,940 sits at the intersection of three active scientific domains: dopaminergic transporter pharmacology, eugeroic compound profiling, and CNS stimulant SAR research. Its value derives from the structural specificity introduced by bis-fluoro substitution — and the distinct preclinical effects that modification produces compared to Modafinil and Adrafinil.

1. Dopaminergic Transporter (DAT) Studies

The most published application of CRL-40,940 in laboratory settings. Preclinical voltammetry and microdialysis research (Keighron et al., 2019) demonstrates that fl modafinil modulates dopamine dynamics in the nucleus accumbens shell with greater potency than Modafinil. Researchers use it to map DAT occupancy, dopamine overflow kinetics, and reuptake inhibition thresholds in controlled animal models.

2. Wakefulness and Vigilance Circuit Research

FLModafinil serves as a probe in studies mapping wake-promoting and vigilance-sustaining neural circuits in preclinical models. Researchers studying the neuroanatomy and neurochemistry of wakefulness — as distinct from stimulant-based arousal — use CRL-40,940 to identify circuit-specific contributions to arousal and sustained attention.

3. Cognitive and Attention Signaling Pathway Studies

The DAT selectivity of FLModafinil makes it useful in preclinical studies examining cognitive performance-related signaling, attention modulation, and executive function pathway analysis. Compared to compounds with broader monoamine transporter profiles, CRL-40,940 isolates dopaminergic contributions more cleanly.

4. Structure-Activity Relationship (SAR) and Comparative Analog Profiling

FLModafinil is a key reference point in SAR studies across the eugeroic class. Researchers running comparative profiling studies across Modafinil, Adrafinil, and Fladrafinil (CRL-40,941) use it to examine how para-position fluorine substitution affects DAT binding affinity, duration of action, and metabolic stability.

5. Oxidative Stress and Neuronal Resilience Models

Building on emerging literature examining Modafinil’s effects on brain oxidative stress (Aguiar-Geraldo et al., Metabolic Brain Disease, 2025), CRL-40,940 is studied in models of cellular stress responses, antioxidant enzyme modulation, and neuronal resilience mechanisms in preclinical conditions.

Safe Handling, Storage & Risk Profile

Handling Precautions

• Handle exclusively in a controlled laboratory environment
• Avoid skin and eye contact; use appropriate PPE
• FLModafinil is a CNS-active compound — apply corresponding laboratory safety protocols

Storage Specifications

Store at −20°C in a dry, dark environment. Keep away from light, heat, and moisture at all times. Correct storage is essential for maintaining research-grade purity and compound stability between uses.

For storage inquiries: support@behemothlabz.com

Frequently Asked Questions

Where can I buy FLModafinil (CRL-40,940)?

BehemothLabz offers FLModafinil capsules for sale for laboratory and research use. Each batch is independently tested with a public COA. Visit Behemoth Labz to view current listings and COA documentation.

What is fl modafinil used for in research?

In laboratory settings, fl modafinil (CRL-40,940) is used primarily as a dopamine transporter (DAT) probe in preclinical models. It is studied in DAT selectivity research, wakefulness circuit mapping, comparative SAR profiling, and cognitive signaling pathway analysis. It is not approved for human or veterinary use.

What is the difference between FLModafinil and Modafinil?

FLModafinil is the bis(para-fluoro) derivative of Modafinil, with two fluorine atoms added to the phenyl rings. In preclinical models, CRL-40,940 demonstrates higher DAT binding affinity than Modafinil and does not induce CYP450 enzymes — giving researchers a more selective tool for DAT-focused studies.

Is FLModafinil the same as “flomodafinil”?

Yes. “Flomodafinil” is a common misspelling of FLModafinil. The correct compound name is FLModafinil or fl modafinil — also identified as CRL-40,940, Bisfluoromodafinil, and Lauflumide.

Is FLModafinil a research chemical?

Yes. FLModafinil is classified strictly as a research chemical — it is not approved for human or veterinary use by the FDA or any regulatory body. BehemothLabz supplies it as a research-use-only compound for preclinical laboratory settings.

Is FLModafinil approved for human use?

No. FLModafinil (CRL-40,940) has not been approved by the FDA or any regulatory authority for human or veterinary use. It is sold by BehemothLabz for laboratory research purposes only.

Does FLModafinil induce CYP450 enzymes?

Preclinical data indicate that CRL-40,940 does not induce CYP450 enzyme activity in laboratory models — a property that makes it useful in studies requiring isolation of DAT effects without metabolic confounds.

What is the purity of BehemothLabz FLModafinil Capsules?

Every batch is independently verified by third-party laboratories. A public COA with purity and concentration data is available for each lot on the product listing page.

What is “eugeroic” in pharmacology?

Eugeroic describes a class of wakefulness-promoting compounds distinct from classical stimulants. The term means “good arousal” in Greek. FLModafinil, Modafinil, Adrafinil, and Fladrafinil all belong to this class.

Can international researchers buy FLModafinil? (FLModafinil kaufen)

BehemothLabz ships internationally. Researchers outside the United States — including those searching for FLModafinil kaufen (German: to buy FLModafinil) — should verify the regulatory status of CRL-40,940 in their jurisdiction before ordering, as research chemical import regulations vary by country.

References

1. Keighron, J. D., Quarterman, J. C., Cao, J., DeMarco, E. M., Coggiano, M. A., Gleaves, A., Slack, R. D., Zanettini, C., Newman, A. H., & Tanda, G. (2019). Effects of (R)-Modafinil and Modafinil Analogues on Dopamine Dynamics Assessed by Voltammetry and Microdialysis in the Mouse Nucleus Accumbens Shell. *ACS Chemical Neuroscience, 10*(4), 2012–2021. https://pubmed.ncbi.nlm.nih.gov/30566329/
2. Aguiar-Geraldo, J. M., da Silva, B. S., Possamai-Della, T., Machado-Laureano, M. L., Vitoreti-Vargas, A., Quevedo, J., & Valvassori, S. S. (2025). The impact of modafinil on memory and brain oxidative stress: contrasting effects of acute and chronic administration in healthy rats. *Metabolic Brain Disease, 40*(5). https://pubmed.ncbi.nlm.nih.gov/40080272/

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