Epithalon (Nasal Spray) – Product Details

Epithalon, also called Epitalon or Epithalone, is a synthetic tetrapeptide composed of four amino acids: Ala-Glu-Asp-Gly (AEDG). It was developed based on the amino acid composition of Epithalamin, a peptide complex derived from the pineal gland. Studies indicate that it may influence cellular processes such as telomere length regulation, DNA repair, and enzyme activity, including telomerase, under experimental conditions.

Research also shows that Epithalon can affect mitochondrial function and energy metabolism in cell models. It has been linked to reductions in oxidative stress, protection of mitochondrial DNA, and modulation of gene expression related to energy balance. These observations highlight its potential to support cellular homeostasis and investigate mechanisms of aging in experimental systems.

Working Mechanism of Epithalon

In research, Epithalon is studied for its effects on cellular aging. It can increase telomerase activity and help maintain telomere length in cell models. Telomeres are protective DNA caps that shorten with cell division. Epithalon also reduces oxidative stress by lowering reactive oxygen species in experimental systems. These actions are studied as ways to support cellular stability and molecular health in research settings.

Properties of Epithalon

CAS Number: Not applicable
Molar Mass: 302.26 g·mol⁻¹
Chemical Formula: C14H24N4O8
IUPAC Name: (2S)-2-[[2-[[2-[[2-amino-3-(carboxypropanoyl)amino]-3-carboxypropanoyl]amino]-3-carboxypropanoyl]amino]butanoic acid

Note: If you’re exploring nasal spray-based peptides, don’t miss out on our complete Nasal Sprays collection for more research options. Additionally, you may find interest in DSIP (Delta Sleep-Inducing Peptide) and GHRP-2 Nasal Spray, two other well-regarded compounds in this category. Each is provided with quality and research integrity in mind.

Research Findings

Studies have shown that Epithalon can influence telomere length and telomerase activity in cultured cells. In experiments with human cell lines, treatment with the tetrapeptide was associated with increased expression of the telomerase catalytic subunit (hTERT) and higher telomerase enzyme activity. These changes were linked with measurable extension of telomere length in both normal and cancer cell models, suggesting that Epithalon may affect cellular mechanisms involved in maintaining chromosome end stability under experimental conditions.

Another research has examined how Epithalon’s antioxidant properties affect cells exposed to stress. In in vitro models of high glucose–induced damage, the peptide showed the ability to reduce oxidative stress markers and support cellular wound healing processes. While this study focused on retinal cells under experimental stress, it highlights how Epithalon may modulate reactive oxygen species and gene expression related to stress responses in research conditions.

Note: Epithalon is not approved by the FDA for medical use. It is available for research purposes only.

Why Buy Epithalon Nasal Spray From Behemoth Labz?

Behemoth Labz has established itself as a reliable and reputable source for research compounds since 2014. We take pride in offering the highest-quality products that are backed by independent, third-party-issued Certificates of Analysis for identification, purity, and concentration.

Our commitment to quality extends to every aspect of our business, from same-day processing to free shipping on all orders over $100 and our satisfaction guarantee.

At Behemoth Labz, we understand the importance of having access to the best compounds for research purposes. Our team is dedicated to providing exceptional customer service and ensuring that our customers have access to the compounds they need to conduct groundbreaking research.

We also offer international shipping to our customers around the world. Our team is committed to ensuring that your order arrives after research is needed to fully understand its mechanisms of action and potential applications for cellular and molecular research..

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Reference Links

Al-dulaimi, S., Thomas, R., Matta, S., & Roberts, T. (2025). Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activity. Biogerontology, 26(5). https://doi.org/10.1007/s10522-025-10315-x

Gatta, M., Dovizio, M., Milillo, C., Ruggieri, A. G., Sallese, M., Antonucci, I., Aleksandr Trofimov, Vladimir Khavinson, Trofimova, S., Bruno, A., & Ballerini, P. (2025). The Antioxidant Tetrapeptide Epitalon Enhances Delayed Wound Healing in an in Vitro Model of Diabetic Retinopathy. Stem Cell Reviews and Reports. https://doi.org/10.1007/s12015-025-10911-x